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Abstract
Protein nuclear bodies (PML-NBs) are dynamic nuclear protein
aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques
have been employed to identify PML-NB proteins. Here we present a manually curated
network of the PML-NB interactome based on extensive literature review including database information. By compiling ‘the PML-ome’, we highlighted the presence of interactors in
the Small Ubiquitin Like Modifier (SUMO) conjugation pathway. Additionally, we show an
enrichment of SUMOylatable proteins in the PML-NBs through an in-house prediction algorithm. Therefore, based on the PML network, we hypothesize that PML-NBs may function as
a nuclear SUMOylation hotspot.
References
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